I am currently en-route to Lima. The last stretch of meetings this year. Whaddayaknow it’s November. It’s been a long bumpy ride and I can’t wait to get it done and over with. Through out the year I’ve had a mix of successes and failures. I won some and then lost some. Many personal wins, but work wise, i am burnt out.
I’d usually be burnt out towards the end of the year, right after all the meetings, but this year it came early. I didn’t even have time to recover before i had to travel again. (I’m not humblebragging ni ah.. just putting out a caveat… huhu I’ve been following Vivy Yusof’s fall from grace and honestly it’s terrifying. It’s a reminder—if you have money or have made it in life, jangan tah show off, just shut the fuck up and fuck off with your millions.Matt and I we share this joke based on a mem on ig “if i have money, i will not say anything but there will be signs”—like topping up your car battery water with Fiji)
…the cabin crew just came over with tea and cake and a serviette with a blue windmill stamped on it. I always dread taking KLM flights cause of the lack of leg space but today im on one of those lucky flights where no one’s sitting in the middle. so i have ample room to wiggle.
yum its dutch apple cake!
aku ani ada adhd kali sebenarnya. i should get it diagnosed. ariatu lupa ku tanya therapist ku. i did ask him if i was bipolar. i asked him this cause i was going through a tough time at work jua… being the self-aware person that i am could feel mcm i was having mood swings bah. i couldnt get up for work, i hated the drive to work..mcm this feeling of dread would come and go and for a moment there i really thought i should have it checked out. skali baik jua nada papa..when i asked him if i was bipolar he looked at me quizzically and flipped through his notes (takut ku sudah) and reassured me, “syazwana, u dont. your feelings are validated, you are going through a tough time”. i was like THANK FUCKING GOD. now i just need have that health scan scheduled… heh.
oh and of course, ill remind to bring up adhd the next time im in therapy.
anyway, back to what i was saying long hours, tight deadlines, and projects that felt like i am jumping through hoops of fire. My colleague and I took it all in stride. We adapted and delivered. And yet, as the December trip approaches, we’ll find ourselves on the sidelines watching the plane take off without us.
Ultimately i have to remind myself that I am more than that trip that i was really looking forward to at the end of the year..recognition isn’t always about where we’re seated or which room we’re in. I shouldn’t give people the power to invalidate my achievements.
So now, the game plan for the next 10 days is not to let anxiety take over and control what you can control – in this case, i’m going to give this last assignment my best. it is not to overshine anyone, god no – but i’m doing it for me.
*makan kopiko 10 biji*
kiss me.
damn I was so happy to see a new post dated November 20 frikking 24. honestly, I come here every now and then to go back to the older posts and was so happy to be greeted by new ones.
apakan. anyway. fangirling since 2008!
To further investigate the stability and conformational changes in ligand-bound protein methods,
principal part analysis (PCA) and free power panorama (FEL) profiles
had been generated from MD trajectories. A side-by-side comparability of the PCA and FEL profiles for all systems is
introduced in Fig 10. In the AR systems (Figs 10A-10B), both complexes exhibit conformational stability, evidenced by
a single large vitality basin close to the minimal variability regions of PC1 and PC2.
In distinction, the ER? system complexed with ecdysterone (Fig 10C) exhibits
a lack of stability, as indicated by the formation of
a quantity of secure power states, unlike its complex with the native ligand (Fig 10D), which is the best definition of anabolic steroids?; https://Medicina-centrum.Cz, remains
secure.
Bioactivation of the prohormone into the potent anabolic steroid 17?-hydroxy-5?-androst-1-en-3-one (1-testosterone) outcomes
from oxidation at carbon 3 of the A-ring and discount at carbon 17 of the D-ring of the steroid nucleus (156).
In those receiving 1-androsterone, serum creatinine levels elevated considerably from 97.3
?mol/L (1.1 mg/dL) to 115.zero ?mol/L (1.3 mg/dL).
Supraphysiological dosages of testosterone, no less than up to 600 mg testosterone enanthate, didn’t affect serum prostate-specific antigen (PSA) ranges in both
healthy younger (15, 22) and older males (37).
Prostate quantity, as assessed by magnetic resonance imaging
(MRI), remained unchanged in response to graded dosages as a lot as 600 mg testosterone enanthate weekly for 20
weeks in healthy males (22). The HAARLEM examine did find a small
but important enhance in PSA levels on the finish of
an AAS cycle in contrast with baseline (from 0.seventy one ?g/L to zero.ninety three ?g/L) (39).
Two % of the topics exceeded the higher limit of the
reference range (2.zero ?g/L). These results are seemingly at odds with the literature that exhibits unchanged PSA ranges in response to supraphysiological dosages of testosterone
enanthate.
It is accepted that the administration of anabolic steroids to wholesome ladies and children has an anabolic effect, and that with the virilizing
results, there is a acquire in muscle mass and power.
Nonetheless, for a few years, it was tough to show conclusively that the
administration of these steroids had a myotrophic effect in wholesome young sportsmen, as discussed
by Ryan (1976) (see the part ‘Anabolic steroids as performance
enhancers in sport’). It was subsequently reasoned that any potential myotrophic effect from administration of anabolic steroids
to eugonadal males could be by way of an anticatabolic mechanism rather
than a direct anabolic effect. Indeed, Antonio et al.
speculate that upregulation might happen with the administration of pharmacological
quantities of androgens, converting muscular tissues that usually have a
minor, or no response, to muscular tissues with enhanced androgen responsiveness.
With respect to males, a most complete evaluation in 1976 of earlier outcomes concluded that
there was little proof for supraphysiological doses
of testosterone or synthetic anabolic steroids having any appreciable impact
on muscle size or strength in wholesome males (Ryan, 1976).
Even so, most of the research reviewed had a lack of
sufficient management and standardization.
This is very worrisome as there’s appreciable proof that myocardial harm, which
can accumulate in years of ongoing AAS use, is a primary trigger for sudden cardiac dying in AAS customers (217).
A few reviews within the literature have linked
AAS use to focal segmental glomerulosclerosis (FSGS) (169–171).
FSGS is a histopathological finding marked by glomerular
lesions, mediated by various insults directed to,
or inherent inside, the podocytes (172). Herlitz et al.
were the primary to current a case series of nine sufferers who developed FSGS after extended AAS
use (169).
Deca Durabolin has minimal antagonistic effects on vital organs;
nonetheless, it can be disadvantageous in phrases of sexual well being, causing erectile dysfunction in some of our patients (typically when used alone).
Testosterone is essentially the most cardiovascular-friendly anabolic steroid
in our expertise, only causing delicate increases in cholesterol scores.
Regardless Of not being the most ‘powerful’ anabolic steroid, we nonetheless see testosterone producing spectacular features in measurement and strength.
Thus, bodybuilders have the choice to make use of an AI (aromatase inhibitor) to inhibit estrogenic-related unwanted
effects of Dianabol, preventing gynecomastia and water weight (2).
Masteron is actually DHT with a methyl group at
the 2nd carbon (known as carbon alpha) atom has been added.
This modification is what is thought to be answerable for the slight anabolic energy increase compared to Testosterone.
This methyl group addition will increase the anabolic strength by
the use of granting Masteron an elevated resistance to being metabolized into
inactive metabolites by the enzyme 3-hydroxysteroid dehydrogenase.
It is also value noting that injecting at the incorrect location can result in paralysis or demise.
Thus, although it might be argued that injectable steroids are safer
in regard to having decreased hepatotoxicity, administering them is probably lethal to the inexperienced.
Furthermore, needle contamination is an extra risk; thus,
users must be wary of hygiene and the sharing of needles.
In most bodybuilders who make the most of average to excessive dosages
of testosterone, blood pressure will rise, with the severity depending
on the dose and cycle period.
After evaluating the molecular results of ligand binding on the receptor, we used Rg to investigate the folding dynamics of the protein throughout time.
Rg values fluctuate over time in an improperly folded conformation, but stable gyration values
are often maintained by a correctly folded conformation. The advanced of ER? with Ecdysterone (Fig 3B) demonstrated a complicated community of molecular interactions, together with hydrogen bonding, hydrophobic interactions, and electrostatic forces and dipole-dipole interactions contributing
to the binding stability and specificity.
The amine group of Arg394 fashioned a stable hydrogen bond with hydroxyl group of Ecdysterone spanning at a distance of two.08 ?.
The receptor has an N-terminal activation function-1 (AF-1) and a second activation function-2 (AF-2) within the C-terminal ligand-binding area.
The mechanisms of AF-1 and AF-2 gene activation, with emphasis on AF-1 and AF-2 conformation and co-activator binding, have
been reviewed by Warnmark et al. (2003). AF-2 is dependent on ligand binding to
the receptor for its exercise, which causes the folding of a C-terminal helix (helix-12), acting
as a lid over the ligand pocket upon ligand
binding.
Anabolic steroids are the most typical appearance- and performance-enhancing medicine (APEDs).
Roughly three to 4 million folks in the Usa use anabolic steroids for nonmedical
functions. For different anabolic steroids, the detection is even simpler, as metabolites
of different unique analogues and derivatives are very easy to determine as quickly
as known.